SLU-PP-332 (5mg)

SLU-PP-332 is a synthetic peptide that selectively activates estrogen-related receptor alpha (ERRα) to mimic the metabolic effects of endurance exercise.

Overview
SLU-PP-332 is a research-grade synthetic peptide developed at Saint Louis University, designed to act as a selective agonist of ERRα, a nuclear receptor that regulates mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation. Unlike non-selective metabolic modulators, SLU-PP-332 does not interact with estrogen receptors or other steroid pathways, making it a precise tool for studying energy metabolism in preclinical models.

Mechanism of Action
When SLU-PP-332 binds to ERRα, it activates transcriptional programs normally triggered by endurance exercise, including:
Upregulation of PGC-1α, the master regulator of mitochondrial gene expression
Increased mitochondrial density and oxidative enzyme activity in skeletal and cardiac muscle
Enhanced fatty acid oxidation and energy expenditure
Improved substrate utilization, as indicated by reduced respiratory exchange ratio (RER) in animal studies. This activation mimics the cellular effects of aerobic exercise without requiring physical activity, which is why SLU-PP-332 is classified as an exercise mimetic.

Preclinical Evidence
In rodent studies, SLU-PP-332 has demonstrated:
50–70% increases in running endurance
Improved insulin sensitivity and glucose control
Reduced liver fat accumulation
Elevated resting metabolism and enhanced fat oxidation

These effects occur even in the absence of exercise, highlighting its potential as a research tool for studying metabolic disease, mitochondrial dysfunction, and exercise physiology.

Research Context
SLU-PP-332 is non-hormonal, meaning it does not suppress endogenous hormone production. It is strictly a research compound and has not been approved for human clinical use, with all current data derived from preclinical studies. Proper storage and handling are critical to maintain its activity, typically lyophilized at −20°C and reconstituted with bacteriostatic water.

Revolution Health & Wellness
SLU-PP-332 is a precision research peptide targeting ERRα to study energy metabolism
It mimics endurance exercise at the cellular level without physical exertion
Preclinical studies show enhanced mitochondrial function, fat oxidation, and endurance
It remains experimental and is not a therapeutic or performance-enhancing drug for humans

SLU-PP-332 represents a powerful tool for researchers exploring metabolic regulation, mitochondrial health, and exercise mimetics, providing insights into pathways that could inform future therapies for metabolic disorders.

DISCLAIMER

EDUCATION PURPOSES ONLY. THIS INFORMATION IS IN NO WAY TO BE USED TO CURE, DIAGNOSE OR TREAT ANY CONDITION(S)