What is Peptide VIP (Vasoactive Intestinal Peptide)?

Vasoactive Intestinal Peptide (VIP) is a 28‑amino‑acid neuropeptide that functions as both a neurotransmitter and a hormone, naturally produced in the hypothalamus, gastrointestinal tract, lungs, immune cells, and other tissues Jay Campbell+1. It was first isolated from porcine intestine in 1970 and is known for its vasodilatory, anti‑inflammatory, and immunomodulatory effects www.peptidedeck.com.

How It Works

VIP binds primarily to VPAC1 and VPAC2 receptors (and PAC1 in some contexts), activating cAMP‑dependent signaling pathways. This leads to:

• Smooth muscle relaxation (vasodilation, bronchodilation)
• Reduced inflammation by suppressing pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑12) and boosting anti‑inflammatory ones (IL‑10, TGF‑β) www.peptidedeck.com+1
• Immune regulation by shifting T‑helper cell differentiation toward regulatory T‑cells (Tregs) www.realpeptides.co
• Circadian rhythm control via the suprachiasmatic nucleus extension.health
• Gut motility and secretion regulation Jay Campbell+1

Biological Roles

VIP influences multiple systems:

• Cardiovascular: Vasodilation, improved blood flow, reduced pulmonary artery pressure extension.health
• Respiratory: Bronchodilation, reduced lung inflammation (useful in asthma, COPD, pulmonary hypertension) www.peptidedeck.com+1
• Gastrointestinal: Regulates gut motility, secretion, and mucosal health Jay Campbell+1
• Immune: Modulates immune tolerance and inflammatory responses www.realpeptides.co+1
• Neurological: Supports cognitive function, reduces neuroinflammation extension.health

Therapeutic Uses

VIP is studied and used in:

• Chronic Inflammatory Response Syndrome (CIRS) — to restore regulatory neuropeptide balance after biotoxin exposure www.peptidedeck.com
• Autoimmune and chronic inflammatory conditions — by balancing immune responses extension.health
• Respiratory diseases — asthma, COPD, pulmonary arterial hypertension www.peptidedeck.com+1
• Gut motility disorders — such as irritable bowel syndrome extension.health
• Cardiovascular support — improving circulation and oxygen delivery extension.health

In summary: VIP is a versatile peptide with broad physiological effects, valued for its ability to reduce inflammation, improve circulation, regulate immune responses, and support respiratory and gut health. It is used both in research and clinical protocols for a range of chronic and inflammatory conditions.